1Syed Faisal

1Tata Memorial Hospital

Background(s):

To determine the efficacy and safety of cryoablation in patients unresectable with desmoid tumors which was progressed on chemotherapy retrospectively at a single institution for the period of 1 year.

Material(s) and Method(s):

A retrospective, single-institution review identified 10 patients (age: 4-45) with extra-abdominal desmoid tumors who received CT-guided percutaneous cryoablation salvage treatment in total 14 sessions in the year 2021. Median maximal lesion diameter was 6 cm .Intent was palliative in all patients. Contrast-enhanced cross-sectional imaging was obtained before and after treatment in addition to routine clinical follow-up.

Result(s):

Technical success was achieved in all patients. The median follow-up was 5 months. Symptomatic improvement was demonstrated in 85 % of patients. At 3 months, the average change in viable volume was -75% and response by modified response evaluation criteria in solid tumors (mRECIST) was PR 70%, and SD 30% .No rapid postablation growth or track seeding was observed. No major procedure related complications were noted

Conclusion(s):

Cryoablation for desmoid tumors demonstrates a high degree of symptom improvement and local tumor control on early follow-up imaging with relatively low morbidity.