1Wessam Fathi Mohammed Mustafa,1.2Ibrahim El-Menshawy

1Mansoura University Hospital, 2Mansoura University Hospital

Background(s):

This study was designed to evaluate the role of vascular endothelial growth factor in AVM associated seizures

Material(s) and Method(s):

A case-control study conducted on 40 patients subdivided into 3 groups on Mansoura university hospital

The patients subdivided into three groups:

  • 10 patients: AVM with seizures.
  • 16 patients: AVM without seizures.
  • 14 patients (control): patient without AVM.

Plasma samples were collected from 40 patients to detect the basal level of VEGF. The serum samples were immediately centrifuged and frozen at -80 C, VEGF were measured by commercially available ELISA (double-antibody sandwich enzyme linked Immunosorbent Assay) kits (Human vascular endothelial cell growth factor ELISA Kit, SUNRED Biological Technology)

Data were fed to the computer and analyzed using IBM SPSS software package version 22.0.Significance of the obtained results was judged at the 0.05 level.

Result(s):

There was statistically significant higher mean of VEGF among AVM cases in comparison to control group, also the VEGF mean value was statistically significant higher among epileptic cases than cases without epilepsy

Conclusion(s):

Our results confirmed the role of VEGF in both AVM and epilepsy and it may be used in future as a reliable and valid predictor. Regarding the debate of the role of VEGF in epilepsy, whether if it’s a neuroprotective or it’s epileptogenic, our study tilting the balance heavily in favour of the epileptogenic effect of VEGF. This study not only gives a hope for using VEGF as a predictor tool in AVM and epilepsy but also VEGF may have a role in future treatment.